Chronic Inflammatory Response Syndrome (CIRS) is a condition discovered and researched by Dr. Ritchie Shoemaker. The proper definition of Chronic Inflammatory Response Syndrome (CIRS) is “An acute and chronic, systemic inflammatory response syndrome acquired following exposure to the interior environment of a water-damaged building (WDB) with resident toxigenic organisms, including, but not limited to fungi, bacteria, actinomycetes and mycobacteria as well as inflammagens such as endotoxins, beta glucans, hemolysins, proteinases, mannans and possibly spirocyclic drimanes; as well as volatile organic compounds (VOCs).”

CIRS involves a systemic inflammatory response that results when an individual does not have the immune response genes to eliminate neurotoxins produced by their exposure to a WDB. So their innate immune system fails to regulate inflammation.

Biotoxins directly affect nerve cell function (http://www.survivingmold.com/diagnosis/the-biotoxin-pathway). CIRS affects multiple systems in the body, causing patients to exhibit multiple symptoms. A patient who presents with several of these, after exposure to a WDB, could be suffering from CIRS.


Symptoms can include fatigue, weakness, aches, muscle cramps, unusual pain, ice pick pain, headache, light sensitivity, red eyes, blurred vision, tearing, sinus problems, cough, shortness of breath, abdominal pain, diarrhea, joint pain, morning stiffness, memory issues, focus/concentration issues, word recollection issues, decreased learning of new knowledge, confusion, disorientation, skin sensitivity, mood swings, appetite swings, sweats (especially night sweats), temperature regulation or dysregulation problems, excessive thirst, increased urination, static shocks, numbness, tingling, vertigo, metallic taste, tremors, multiple chemical sensitivities.

Depending upon their symptoms, patients may be diagnosed with other illnesses, including multiple sclerosis, chronic fatigue syndrome, fibromyalgia, and depression; however, there are tests that can be used to establish if CIRS is the underlying cause of their symptoms.


Some CIRS sufferers recover naturally over a period of time, once removed from the WDB. Others will require medication such as cholestyramine to remove toxins from their systems, hormone replacement therapy, and a toxin-free home and work environment until their immune system has had time to recover and heal itself.

Biofilm producing Multiple Antibiotic Resistant Coagulase Negative Staph aureas (MARCoNS) in CIRS patients.

Shoemaker recommends eradication of nasal and sinus MARCoNS with a combination antibiotic BEG nasal spray. BEG contains Bactroban (Mupirocin) 0.2% EDTA Disodium 1% and Gentamycin 0.5% Nasal Spray. The EDTA’s roll is to disrupt the biofilm so the antibitics can kill the Staph.

A nasal MARCoNS and fungus/mold combined swab test is now available in Australia to appropriately diagnose if this is appropriate.

If a fungus is present an anti-fungal Amphoteracin nasal spray is required.

These treatments are available from us on prescription.

For more information Dr. Shoemaker has a website www.survivingmold.com that contains a large amount of free information and resources on biotoxin related illness in general, and CIRS-WDB in particular.

For support within Australia on toxic mold – visit http://www.toxic-mould-support-australia.org/

This article is from Custommedicine. https://custommedicine.com.au/health-articles/cirs-chronic-inflammatory-response-syndrome/


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