Immune System



Chronic low grade inflammation is actually pretty common, it is known as Metainflammation and is linked to our modern lifestyles. It is linked to chronic illness and also ongoing unwellness and unpleasant symptoms for which there is no obvious medical cause. That is FND/CSS pain syndromes and related including depression.

Metainflammation can be helped by treatments as necessary and by following Self Management guidelines - healthy diet, sleep, exercise, stress management, life/work balance.

But if your MAST CELLS ARE BEHAVING BADLY and over reacting, your symptoms may persist if you do not reduce your exposures to mastcell activators.  Unfortunately there are lots of these.

 foodstuff (histamine, sometimes salicylates) , chemicals, pollutants, fragrances, pathogens - bacteria, virus, parasites, fungi, and other including Aspirin, NSAIDS other, if you have pseudo allergies (Vasomotor, pharmaceutical food intolerance, HIT).

"Mast Cells behaving badly"  and changes to toll like receptors (Threat receptors) are known to be considerable problem in some people with FND/CSS Pain syndromes (R).  These have been associated with  Chronic Fatigue Syndrome and Fibromyalgia and related pain syndromes and are thought to also be associated with infections (R), and other things .  In patients with CFS who also have POTS,   Mast Cell Activation Syndromes (MCAS) ,   is thought to be common.

IMPORTANT NEWS Griffith University research has identified a defective cell receptor in the immune system of people with chronic fatigue syndrome which they hope will lead to a definitive test for the disorder and eventually, an effective treatment. see here


Mast Cells, and inflammationchronic pain and fatigue syndromes (e.g. fibromaylia, Chronic Fatigue syndrome)

Australian scientists have linked chronic fatigue syndrome (CFS) to a genetic defect in immune cell receptors putting to rest once and for all the pathology of this much-maligned condition.

The research undertaken by the National Centre for Neuroimmunology and Emerging Diseases (Griffiths University) found that an inherited genetic defect means that cells do not work optimally.

These findings have potentially wider implications as many of the patients studied also had fi- bromyalgia and postural orthostatic tachycardia syndrome.

Mast-cell precursors have also been found in the blood of the patients studied. Whilst CFS pa- tients might well fall under the spectrum of mast-cell activation, the Griffiths University re- search, by identifying the mechanism of action, provides a much more precise diagnosis. found at


Immune System Abnormalities

CFS has sometimes been referred to as the “chronic fatigue immune dysfunction syndrome.” A number of studies have found irregularities of the immune system. Sometimes the immune sys- tem overreacts, and sometimes it underreacts, but no consistent picture has emerged to con- firm that CFS is a disease of the immune system.

Allergies. Some studies have reported that a majority of CFS patients have allergies to foods, pollen, metals (such as nickel or mercury), or other substances. One theory is that allergens, like viral infections, may trigger a cascade of immune abnormalities that lead to CFS. However, most allergic people do not have CFS.

Autoimmune Abnormalities. The risks for chronic fatigue syndrome are similar to the risks for a number of autoimmune diseases. However, it is not clear whether people with CFS have the au- toantibodies (antibodies that attack the body’s own tissues) found in people with autoimmune disorders. It is not likely that CFS is caused by autoimmunity. – http://www.umm.e- du/health/medical/reports/articles/chronic-fatigue-syndrome

Sources: Griffith University


Novel characterisation of mast cell phenotypes from peripheral bloodmononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients. ...https://www.ncbi.nlm.nih.- gov/pubmed/27362406by T Nguyen – 201

Spectrum of mast cell activation disorders. – NCBI – NIH https://www.ncbi.nlm.nih.- gov/pubmed/24784142 by AI Petra – 2014

Salicylate Intolerance Pathophysiology, Clinical Spectrum, Diagnosis and Treatment ...

In intolerant individuals, there is also activation of basophiles and eosinophiles, macrophages, mast cells, platelets, and lymphocytes. These cells play an essential role in the symptoms (2, 3, 4, 5, 6, e4, e5, e6, e7, e8, e9).

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic op- tions

In Search of a Germ Theory Equivalent for Chronic Disease Garry Egger, PhD, MPH

Inflammation and Disease Metaflammation and Anthropogens

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